The most powerful and important aspect of the immune system involves the body's probiotic bacteria. The human body houses more than 32 billion beneficial and harmful bacteria and fungi at any particular time. When beneficial bacteria are in the majority, they constitute 70-80% of the body's immune response.
This takes place both in an isolated manner and in conjunction with the rest of the immune system.
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Probiotic colonies work with the body's internal immune system to organize strategies that prevent toxins and pathogenic microorganisms from harming the body. Probiotics communicate and cooperate with the immune system to organize cooperative strategies. They stimulate the body's immune cells, activating the cell-mediated response, the humoral response, and indirectly, the body's exterior barrier mechanisms through immunoglobulin stimulation. Three decades of medical research has indicated that probiotics stimulate T-cells, B-cells, macrophages and NK-cells with smart messages that promote specific immune responses. They also activate cytokines and phagocytic cells directly to coordinate their intelligent immune response.
Probiotics can quickly identify harmful bacteria or fungal overgrowths and work to eradicate them. This process may not directly involve the rest of the immune system. Even still, the immune system will be notified of any probiotic offensives. The immune system will support the process by breaking up and escorting dead pathogens out of the body.
Probiotics produce chemical substances that destroy invading microorganisms. Probiotics make up our body's own antibiotic system. Because probiotics want to survive, they have developed various strategies to defend their host (our body). It is a territorial issue. Invading bacteria threaten their homes and families. Probiotics also learn how to fight newer bacteria species and new bacteria strategies. While static pharmaceutical antibiotics are counteracted by smart super-bugs, probiotics can alter their antibiotic strategies as needed. Our continued survival illustrates their intelligence.
Probiotics produce antimicrobial biochemicals that manage, damage or kill pathogenic microorganisms. In some cases, they will simply overcrowd the invaders with biochemistry and populations to limit their growth. In other cases, they will secrete chemicals into the fluid environment to eradicate large populations. In still other cases, they will insert specific chemicals into the invaders, which will directly kill them. Probiotic mechanisms are quite complex and variegated to say the least.
For example, lactic acid produced by Lactobacillus and Bifidobacteria species sets up the ultimate pH control in the gut to repel antagonistic organisms. Lactic acids are not alike, however. There are different lactic acid molecular structures, and combinations with other chemicals. Many probiotic strains also produce a molecular combination with hydrogen peroxide called lactoperoxidase.
Probiotics also produce acetic acids, formic acids lipopolysaccharides, peptidoglycans, superantigens, heat shock proteins and bacterial DNA-all in precise portions to nourish each other, inhibit challengers and/or benefit the host.
Precision and proportion is the key. For example, some bifidobacteria secrete a 3:2 proportion of acetic acid to lactic acid in order to barricade certain pathogenic bacterial.
Probiotics also secrete a number of key nutrients crucial to its host's (our body) immune system and metabolism, including B vitamins pantothenic acid, pyridoxine, niacin, folic acid, cobalamin and biotin, and crucial antioxidants such as vitamin K.
Probiotics also produce antibacterial molecules called bacteriocins. Lactobacillus plantarum produces lactolin. Lactobacillus bulgaricus secretes bulgarican. Lactobacillus acidophilus can produce aciophilin, acidolin, bacterlocin and lactocidin. These and other antibacterial substances equip probiotic species with territorial mechanisms to combat and reduce pathologies related to Shigella, Coliform, Pseudomonas, Klebsiella, Staphylococcus, Clostridium, Escherichia and other infective genera. Furthermore, antifungal biochemicals from the likes of L. acidophilus, B. bifidum, E. faecium and others also significantly reduce fungal outbreaks caused by Candida albicans.
These types of antimicrobial tools give probiotics the ability to counter the mighty H. pylori bacterium-known to be at the root of a majority of ulcers. H. pylori inhibition has been observed in studies on L. acidophilus DDS-1, L. rhamnosus GG, L. rhamnosus Lc705, Propionibacterium freudenreichii and Bifidobacterium breve Bb99.
Furthermore, probiotics will specifically stimulate the body's own immune system to attack pathogens. For example, scientists from Finland's University of Turku gave nine atopic dermatitis children Lactobacillus rhamnosus GG for four weeks. They found that serum cytokine IL-10 levels specific to the infection increased following probiotic consumption.
Whatever the strategy, smart probiotic microorganisms work collectively and synergistically with the other components of our immune system. Our probiotic system works within the non-specific immune system to help protect the body from invasions. Probiotics live within the oral cavity, the nasal cavity, the esophagus, around the gums, and in pockets of our pleural cavity (surrounding our lungs). They dwell within our stomach, within our intestines, within the vagina and around the rectum, and amongst other pockets of tissues. This means that for bacteria to invade the bloodstream, they must first get through legions of probiotic bacteria that populate those entry channels-assuming a healthy body of course.
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