The natural products store in North America is saturated with products that claim to boost the metabolism to take off the pounds. You can find a hydroxycut caffeine-free fat burner, a liquid gel green tea product, and a variety of supplements that claim to literal, "glucose intolerance" (the mainstream term is "insulin resistance") specifically to help diabetics lose weight. A investigate study published just in February 2008, however, suggests that a combination of two safe and reasonable supplements may:
Enlarge and open the mitochondria ("energy machinery") inside adipose tissue to oxidize lipids
Activate insulin to converyance glucose and fatty acids out of the bloodstream to fat cells with these activated mitochondria and
Do all this without accelerating the heart rate or interfering with the performance of thyroid hormones.
These two supplements are lipoic acid and L-carnitine.
Hydroxycut
Alpha-lipoic acid, or Ala as it's commonly called, counteracts the glycation, or "caramelizing" of hemoglobin proteins in the blood. This takes stress off the kidneys, and it also gives diabetics lower HbA1C numbers at their regular checkups. The most tasteless form of Ala contains a combination of chemical isomers, one of which can be used by the body (R-lipoic acid) and one that can't (the S-form of the same molecule), but every Ala supplement is at least 50 per cent bioavailable.
L-carnitine is not as well known but has some applications in diabetes, too. There's a growing body of evidence that taking 200 to 2,000 mg of L-carnitine a day may protect diabetic brain tissue.
And it was brain specialists at the University of California at Irvine and Shanghai's Institutes of Biological Sciences in China who seem to have uncovered the potential for a combination of lipoic acid and L-carnitine to aid weight control
In investigate just published in February 2008, the scientists exposed adipose cells to lipoic acid, L-carnitine, or a combination of the two. Neither lipoic acid nor L-carnitine by itself had much succeed on the performance of fat cells. Together, however, the two antioxidants caused the power development organelles known as the mitochondria to legitimately grow overnight, burning more fatty acids and more glucose.
The combination of lipoic acid and L-carnitine also stimulated the uptake of fatty acids and sugars in the same way as the drugs Actos and Avandia with one significant difference. Actos and Avandia just get the sugar out of the bloodstream and into storage. Lipoic acid and L-carnitine get the sugar and fat into a fat cell that's primed to burn it.
Overweight Diabetics
While taking 2,000 mg a day of both supplements won't hurt you (be sure to take supplemental biotin if you take lipoic acid), this study does not form with scientific certainty that the combination of lipoic acid and L-carnitine will act as an effective diet aid. The scientists used cells taken from lab rats, not humans, and the level of the experiment was laboratory, not clinical. Still, as a way of improving weight loss without caffeine or thyroid hormone, this study is a very foremost first step.
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